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A comparative study of the cardiopulmonary and sedative effects of a single intramuscular dose of ketamine anesthetic combinations in rabbits.

Authors
  • Cardoso, Clarisse G1
  • Ayer, Ilan M2
  • Jorge, Adriana T1
  • Honsho, Cristiane S1
  • Mattos-Junior, Ewaldo3
  • 1 Veterinary Science Undergraduate Program, University of Franca, Franca, SP, Brazil. , (Brazil)
  • 2 Centro Universitário Una, Pouso Alegre, MG, Brazil. , (Brazil)
  • 3 Veterinary Science Undergraduate Program, University of Franca, Franca, SP, Brazil. Electronic address: [email protected] , (Brazil)
Type
Published Article
Journal
Research in veterinary science
Publication Date
Nov 30, 2019
Volume
128
Pages
177–182
Identifiers
DOI: 10.1016/j.rvsc.2019.11.016
PMID: 31812610
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The aim of this prospective, randomized, blinded crossover study was compare the cardiopulmonary and sedative effects of ketamine in combination with acepromazine, diazepam, dexmedetomidine, midazolam or xylazine, injected intramuscularly in rabbits, using eight one-year-old male New Zealand rabbits (4.1 ± 0.40 kg). All treatments included ketamine (K; 30 mg/kg) in combination with one of the following: acepromazine 0.5 mg/kg (treatment KA); diazepam 1 mg/kg (KD); dexmedetomidine 0.025 mg/kg (KDex); midazolam 1 mg/kg (KM); or xylazine 3 mg/kg (KX) mixed in the same syringe and injected intramuscularly. Cardiopulmonary variables, blood gases and sedative scores were measured before injection (T0 or baseline) and every 10 min thereafter, over a 60-min period. There were reductions in heart rate, compared with the baseline, at all evaluation times in treatment KX. Treatments KDex, KM and KX presented reductions in respiratory rate at all evaluation times, in comparison with the baseline. There were reductions in mean arterial pressure in KA and KX at times T10-T60 and in PaO2 in KDex, KM and KX at T10-T50. The sedation scores were similar in KA, KDex, KM and KX at T10-T20. Ketamine in combination with acepromazine, dexmedetomidine, midazolam or xylazine promoted similar sedative effects for twenty minutes, but the α2-agonists can promote hypoxemia. Copyright © 2019 Elsevier Ltd. All rights reserved.

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