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Comparative studies with linear and cyclic somatostatin on the self-stimulation of rats.

Authors
  • Vécsei, L
  • Schwarzberg, H
  • Telegdy, G
Type
Published Article
Journal
Acta physiologica Academiae Scientiarum Hungaricae
Publication Date
Jan 01, 1982
Volume
60
Issue
3
Pages
165–168
Identifiers
PMID: 6136151
Source
Medline
License
Unknown

Abstract

In the present study the dose-related effects of linear and cyclic somatostatin were compared on the self-stimulation rate of rats. Twenty micrograms of linear somatostatin administered intracerebroventricularly (icv.) markedly decreased the self-stimulation rate, while 5 micrograms and 10 micrograms was ineffective. Cyclic somatostatin in a dose of 1 microgram caused a transitory but not significant increase in the self-stimulation rate, which later returned to the control level. Five micrograms and 10 micrograms of the peptide decreased the self-stimulation rate. These results indicate that the cyclic somatostatin is more effective in inhibiting the self-stimulation rate than the linear one.

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