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Comparative Pharmacodynamics of Three Newer Fluoroquinolones versus Six Strains of Staphylococci in an In Vitro Model under Aerobic and Anaerobic Conditions

Authors
  • David H. Wright
  • Brent W. Gunderson
  • Laurie B. Hovde
  • Gigi H. Ross
  • Khalid H. Ibrahim
  • John C. Rotschafer
Publisher
American Society for Microbiology
Publication Date
May 01, 2002
Source
PMC
Keywords
Disciplines
  • Pharmacology
License
Unknown

Abstract

Six strains of staphylococci were exposed to levofloxacin, moxifloxacin, or trovafloxacin in an in vitro pharmacodynamic model under both aerobic and anaerobic conditions. Each agent demonstrated a rapid 3-log10 kill versus susceptible isolates regardless of condition. Against clinical isolates with reduced susceptibility, regrowth occurred by 24 h and was frequently associated with further increases in MICs.

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