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A comparative pharmacodynamic study of ticagrelor versus clopidogrel and ticagrelor in patients undergoing primary percutaneous coronary intervention: the CAPITAL RELOAD study.

Authors
  • Hibbert, Benjamin
  • Maze, Ronnen
  • Pourdjabbar, Ali
  • Simard, Trevor
  • Ramirez, F Daniel
  • Moudgil, Rohit
  • Blondeau, Melissa
  • Labinaz, Marino
  • Dick, Alexander
  • Glover, Christopher
  • Froeschl, Michael
  • Marquis, Jean-François
  • So, Derek Y F
  • Le May, Michel R
Type
Published Article
Journal
PLoS ONE
Publisher
Public Library of Science
Publication Date
Jan 01, 2014
Volume
9
Issue
3
Identifiers
DOI: 10.1371/journal.pone.0092078
PMID: 24651043
Source
Medline
License
Unknown

Abstract

In patients referred for PPCI, ticagrelor bolus following clopidogrel resulted in more rapid and profound platelet inhibition, demonstrating a positive pharmacodynamic interaction. Further study is needed to determine if this pharmacodynamic effect translates into reduced clinical events.

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