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Comparative genomic hybridization analysis of sperm DNA apoptosis after exposure to heat shock.

Authors
  • Mann, Sylvia L
  • Patton, William C
  • King, Alan
  • Chan, Philip J
Type
Published Article
Journal
Journal of assisted reproduction and genetics
Publication Date
Apr 01, 2002
Volume
19
Issue
4
Pages
195–200
Identifiers
PMID: 12036087
Source
Medline
License
Unknown

Abstract

Fragile DNA were found in a population of sperm associated with poor capacitation characteristics and apoptosis was observed after heat treatment. The results suggested that sperm dysfunction might be due to apoptotic sperm DNA resulting from an elevated temperature in the surroundings. The data suggested that the second population of high capacitating sperm induced chaperones such as heat shock proteins hsp 70 to protect against apoptosis.

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