Affordable Access

deepdyve-link
Publisher Website

Comparative and evolutionary studies of mammalian arylsulfatase and sterylsulfatase genes and proteins encoded on the X-chromosome.

Authors
  • Holmes, Roger S1
  • 1 The Griffith Research Institute for Drug Discovery and School of Natural Sciences, Griffith University, Nathan, 4111 QLD, Australia. Electronic address: [email protected] , (Australia)
Type
Published Article
Journal
Computational biology and chemistry
Publication Date
Jun 01, 2017
Volume
68
Pages
71–77
Identifiers
DOI: 10.1016/j.compbiolchem.2017.02.009
PMID: 28257906
Source
Medline
Keywords
License
Unknown

Abstract

At least 19 sulfatase genes have been reported on the human genome, including four arylsulfatase (ARS) genes (ARSD; ARSE; ARSF; ARSH) and a sterylsulfatase (STS) gene located together on the X-chromosome. Bioinformatic analyses of mammalian genomes were undertaken using known human STS and ARS amino acid sequences to study the evolution of these genes and proteins encoded on eutherian and marsupial genomes. Several domain regions and key residues were conserved including signal peptides, active site residues, metal (Ca2+) and substrate binding sequences, transmembranes and N-glycosylation sites. Phylogenetic analyses describe the relationships and potential origins of these genes during mammalian evolution. Primate ARSH enzymes lacked signal peptide sequences which may influence their biological functions. CpG117 and CpG92 were detected within the 5' region of the human STS and ARSD genes, respectively, and miR-205 within the 3'-UTR for the human STS gene, using bioinformatic methods A proposal is described for a primordial invertebrate STS-like gene serving as an ancestor for unequal cross over events generating the gene complex on the eutherian mammalian X-chromosome.

Report this publication

Statistics

Seen <100 times