Affordable Access

Comparative evaluation of fifteen anti-sickling agents.

Authors
  • Chang, H
  • Ewert, S M
  • Bookchin, R M
  • Nagel, R L
Type
Published Article
Journal
Blood
Publication Date
Apr 01, 1983
Volume
61
Issue
4
Pages
693–704
Identifiers
PMID: 6338971
Source
Medline
License
Unknown

Abstract

Fifteen compounds reported to be inhibitors of gelation or sickling were studied by standard methods. These tests included (1) the determination of the solubility of deoxyhemoglobin S or Csat, (2) evaluation of sickling in whole SS blood at various pO2s, (3) measurement of the oxygen affinity of hemoglobin and blood, and (4) examination of red cell indices and morphology. Among the 4 noncovalent agents tested, butylurea was the most potent inhibitor of gelation and sickling in vitro; however, relatively high concentrations were required compared to the covalent agents. In the latter group, bis-(3,5 dibromosalicyl)-fumarate, nitrogen mustard, and dimethyladipimidate were especially effective inhibitors of gelation and/or sickling. All of these compounds require further development before they can be considered for clinical use.

Report this publication

Statistics

Seen <100 times