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[Comparative evaluation of fibrinogen and fibrin hydrolysis with plasmin].

Authors
  • Kastrikina, T F
  • Taran, L D
  • Makogonenko, E M
  • Kudinov, S A
Type
Published Article
Journal
Ukrainskiĭ biokhimicheskiĭ zhurnal (1978)
Publication Date
Jan 01, 1983
Volume
55
Issue
3
Pages
266–270
Identifiers
PMID: 6223426
Source
Medline
License
Unknown

Abstract

A high-sensitive method is developed for determining the degree of plasmin-catalyzed fibrinogen hydrolysis by the released amino groups stained with trinitrobenzene sulphoacid. The method permits determining 0.02-0.08 casein units of plasmin. The method made it possible to establish that after streptokinase activation plasmin hydrolyzes equally fibrinogen and fibrin in solution and as gel. When a tissue activator is used, fibrin intensifies significantly the plasminogen activation. Inhibition of plasmin by an inhibitor produced from soya is considerably slowed down in fibrin gel.

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