Affordable Access

Access to the full text

Comparative Evaluation of Chemoimmunoradiotherapy and Chemoradiotherapy in the Management of Advanced Head and Neck Cancer

Authors
  • Venkatachalam, V. P.1
  • Bhowmik, K. T.2
  • 1 Safdarjung Hospital, Deptt. of ENT, New Delhi, 110028 , New Delhi
  • 2 Safdarjung Hospital, Deptt. of Radiotherapy, New Delhi, 110028 , New Delhi
Type
Published Article
Journal
Indian Journal of Otolaryngology and Head & Neck Surgery
Publisher
Springer-Verlag
Publication Date
Oct 01, 1998
Volume
50
Issue
4
Pages
345–348
Identifiers
DOI: 10.1007/BF03000685
Source
Springer Nature
Keywords
License
Yellow

Abstract

50 patients of advanced squamous cell carcinoma of the head and neck were randomised cither to receive chemotherapy followed by radiation therapy or chemoimmunotherapy followed by radiotherapy. In the chemoimmunotherapy arm, the patients received recombinant interferon alpha 2b 3 M.U. subcutaneously, thrice a week on alterante days for 5 weeks from Day 1, Cisplatinum 70 mg/ m2 on Day 1 and 21, and 5 — flurouracil 1000mg/m2 on Day 1, 2, 3 and Day 21, 22, 23, followed by from Dav 36, radiotherapy'by Co bait 60 to a tumour dose of 65 Gy in 30 # over 6 weeks. In the control arm, patiens received Cisplatitnum 70 mg/ m2 on Day 1 and Day 21, 5 flurouracil 1000 mg/ m2 on Dav 1, 2, 3 and Day 21, 22, 23 followed by radiotherapy by Cobalt 60 to a tumour dose of 65 Gy in 30 # over 6 weeks from Day 36. Only Grade II and III toxicity was observed in the two arms which were manageable Patients treated with chemoimmunotherapy followed by radiotherapy showed 60% complete response, 20% partial response and 12% no change/ progressive disease; while the patients on the control arm treated with chemotherapy and radiotherapy showed 12% complete response 44% Partial response and 32% no change“ progressive disease. This trial concludes that chemoimmunotherapy followed by radiotherapy is an excellent alternative therapeutic strategy for the management of advanced head and neck cancers with manageable toxicity.

Report this publication

Statistics

Seen <100 times