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Comparative effects of sugars on the hemolytic activity of Schistosoma mansoni and other hemolytic agents.

Authors
  • Kasschau, M R
  • Prill, M S
Type
Published Article
Journal
Comparative Biochemistry and Physiology Part A Physiology
Publisher
Elsevier
Publication Date
Jan 01, 1988
Volume
90
Issue
3
Pages
453–458
Identifiers
PMID: 2901315
Source
Medline
License
Unknown

Abstract

1. The rate of red blood cell lysis by the hemolytic agent in adult worm homogenates of Schistosoma mansoni is slowed in the presence of added sugars (50 mM). 2. Trisaccharides were the most effective in slowing and reducing lysis. Disaccharides were more effective than monosaccharides. 3. The addition of sodium, potassium or lithium chloride salts (25 mM) stimulated hemolysis by the S. mansoni agent. 4. Hemolysins with known mechanisms were tested to determine the effects of added sugars (50 mM) or salts (25 mM). 5. The S. mansoni hemolytic agent responds to the addition of sugars and salts in a manner similar to small membrane pore formers.

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