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Comparative effects of proportional assist and variable pressure support ventilation on lung function and damage in experimental lung injury.

Authors
  • Spieth, Peter M
  • Güldner, Andreas
  • Beda, Alessandro
  • Carvalho, Nadja
  • Nowack, Thomas
  • Krause, Anke
  • Rentzsch, Ines
  • Suchantke, Sabina
  • Thal, Serge C
  • Engelhard, Kristin
  • Kasper, Michael
  • Koch, Thea
  • Pelosi, Paolo
  • de Abreu, Marcelo Gama
Type
Published Article
Journal
Critical Care Medicine
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Sep 01, 2012
Volume
40
Issue
9
Pages
2654–2661
Identifiers
PMID: 22743778
Source
Medline
License
Unknown

Abstract

In a lung lavage model of acute lung injury, both variable pressure support and proportional assist ventilation increased the variability of tidal volume and improved oxygenation and venous admixture, without influencing subject-ventilator synchrony or affecting lung injury compared with pressure support ventilation. However, variable pressure support yielded less inspiratory effort than proportional assist ventilation at comparable mean tidal volumes of 6 mL/kg.

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