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Comparative effects of corticotropin-releasing factor, arginine vasopressin, and related neuropeptides on the secretion of ACTH and α-MSH by frog anterior pituitary cells and neurointermediate lobes in vitro

  • Tonon, Marie Christine
  • Cuet, Pascale
  • Lamacz, Marek
  • Jégou, Sylvie
  • Côté, Jean
  • Gouteux, Laurence
  • Ling, Nicholas
  • Pelletier, Georges
  • Vaudry, Hubert
Publication Date
Mar 01, 1986
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The ability of corticoliberin (CRF), urotensin I, sauvagine, arginine-vasopressin (AVP), and mesotocin to stimulate ACTH release by frog anterior pituitary cells and α-melanotropin (MSH) by frog neurointermediate lobe was studied in vitro using a perifusion technique. CRF and AVP were found to be potent stimulators of ACTH secretion, whereas urotensin I and sauvagine were totally inactive. In opposition to recent findings in the rat, CRF did not modify α-MSH secretion by the frog neurointermediate lobe. Mesotocin, which is present in the parenchymal cells of the frog pars intermedia, had no effect on α-MSH release in vitro. No potentiation of CRF-induced ACTH release was observed when anterior pituitary cells were incubated with a combination of AVP and CRF. Together with the recent elucidation of a CRF-like molecule in the frog diencephalon, these results suggest that, in Amphibia, CRF and AVP exert their stimulatory action specifically on distal lobe corticotrophs.

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