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Comparative effect of truncal vagotomy and pirenzepine on postprandial secretory response of exocrine pancreas in dogs.

Authors
  • Huertas, J R
  • Madrid, J A
  • Martinez-Victoria, E
  • Mañas, M
  • Mataix, F J
Type
Published Article
Journal
Fundamental & clinical pharmacology
Publication Date
Jan 01, 1992
Volume
6
Issue
2
Pages
59–65
Identifiers
PMID: 1376713
Source
Medline
License
Unknown

Abstract

The comparative effect of truncal vagotomy and associated pyloroplasty and orally administrated pirenzepine (75 mg, 1 h before food intake) on the exocrine pancreatic secretory response to food was studied in conscious dogs. Both pirenzepine administration and truncal vagotomy totally abolished the pancreatic hydromineral and organic secretory response to food intake while postprandial pH of intraduodenal content remained above 6. From the results of our study we conclude that the vago nerve must not be altered in order to assure a pancreatic response to food intake and that pirenzepine is as strong as truncal vagotomy in maintaining pH in postprandial intraduodenal content over 6.

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