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Comparative cochlear toxicities of streptomycin, gentamicin, amikacin and netilmicin in guinea-pigs.

Authors
  • Kalkandelen, S
  • Selimoğlu, E
  • Erdoğan, F
  • Uçüncü, H
  • Altaş, E
Type
Published Article
Journal
The Journal of international medical research
Publication Date
Jan 01, 2002
Volume
30
Issue
4
Pages
406–412
Identifiers
PMID: 12235923
Source
Medline
License
Unknown

Abstract

All the aminoglycoside antibiotics now in clinical use are ototoxic. This study was designed to compare the toxic effects of four aminoglycoside antibiotics, streptomycin, gentamicin, amikacin and netilmicin, administered to guinea-pigs systemically (at respective doses of 125 mg/kg, 50 mg/kg, 150 mg/kg or 37.5 mg/kg, twice daily for 1 week) or topically via the transtympanic route (0.25 ml/kg in 4% saline, twice daily for 1 week). Chosen doses were 10-20 times higher than the recommended human dosage. Cochlear damage was observed in all animals that were given systemic and local aminoglycosides. The severity of the cochlear damage was in the order gentamicin, amikacin, streptomycin, netilmicin, with gentamicin being the most toxic. No statistically significant difference between the severity of cochlear damage resulting from the systemic and topical applications was detected.

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