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Comparative Aspects of Nucleotide and Amino Acid Metabolism in Toxoplasma gondii and Other Apicomplexa

Authors
  • Chaudhary, Kshitiz
  • Fox, Barbara A.
  • Bzik, David J.
Type
Book
Journal
Toxoplasma Gondii
Publication Date
Jan 01, 2014
Pages
663–706
Identifiers
DOI: 10.1016/B978-0-12-396481-6.00020-9
ISBN: 978-0-12-396481-6
Source
Elsevier
Keywords
License
Unknown

Abstract

As obligate intracellular parasites, the Apicomplexa must acquire nutrients from their hosts. Amongst the most important nutrients are purines and pyrimidines that form the essential building blocks for nucleic acids and molecules required for energy metabolism. It had been assumed for decades that purine and pyrimidine metabolism would be similar in all protozoa, but detailed study of these pathways has demonstrated that each parasite has evolved its own repertoire of pathways that reflects the unique environmental niches occupied by the Apicomplexa. All Apicomplexa are unable to make purines de novo and must salvage from their hosts. The ability to make pyrimidines varies within each of the parasites. This chapter reviews our current knowledge of the nucleotide and amino acid metabolic pathways for three major Apicomplexa of importance in human disease: Plasmodium species, Cryptosporidium species and Toxoplasma gondii

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