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Compact voltage and current stimulation buffer for high-density microelectrode arrays.

Authors
  • Livi, P
  • Heer, F
  • Frey, U
  • Bakkum, D J
  • Hierlemann, A
Type
Published Article
Journal
IEEE transactions on biomedical circuits and systems
Publication Date
Dec 01, 2010
Volume
4
Issue
6
Pages
372–378
Identifiers
DOI: 10.1109/TBCAS.2010.2080676
PMID: 23850754
Source
Medline
License
Unknown

Abstract

We report on a compact (0.02 mm(2) ) buffer for both voltage and current stimulation of electrogenic cells on a complementary metal-oxide semiconductor microelectrode array. In voltage mode, the circuit is a high-current class-AB voltage follower, based on a local common-mode feedback (LCMFB) amplifier. In current mode, the circuit is a current conveyor of type II, using the same LCMFB amplifier with cascode stages to increase the gain. The circuit shows good linearity in the 0.5-3.5 V input range and has extensively been used for stimulation of neuronal cultures.

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