Affordable Access

Access to the full text

The Common Single-Nucleotide Polymorphism rs2681472 Is Associated With Early-Onset Preeclampsia in Northern Han Chinese Women

Authors
  • Wan, Ji-Peng1
  • Wang, Hong1
  • Li, Chang-Zhong1
  • Zhao, Han2, 3, 4, 5
  • You, Li2, 3, 4, 5
  • Shi, Dong-Hong1
  • Sun, Xiu-Hua6
  • Lv, Hong1
  • Wang, Fei1
  • Wen, Ze-Qing1
  • Wang, Xie-Tong1
  • Chen, Zi-Jiang2, 3, 4, 5
  • 1 Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, 250021, China , Jinan (China)
  • 2 Provincial Hospital Affiliated to Shandong University, Jinan, China , Jinan (China)
  • 3 National Research Center for Assisted Reproductive Technology and Reproductive Genetics, China , (China)
  • 4 The Key laboratory for Reproductive Endocrinology of Ministry of Education, China , (China)
  • 5 Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China , Jinan (China)
  • 6 Qingdao Municipal Hospital, Qingdao, China , Qingdao (China)
Type
Published Article
Journal
Reproductive Sciences
Publisher
SAGE Publications
Publication Date
Nov 01, 2014
Volume
21
Issue
11
Pages
1423–1427
Identifiers
DOI: 10.1177/1933719114527354
Source
Springer Nature
Keywords
License
Yellow

Abstract

Preeclampsia, characterized by hypertension and proteinuria, remains a leading cause of maternal morbidity and mortality. Recently, a genome-wide association study (GWAS) identified the single-nucleotide polymorphism, rs2681472, as a new hypertension susceptibility genetic variant. The purpose of this study was to evaluate the association between preeclampsia and rs268172 in a Northern Han Chinese population. We genotyped 1218 unrelated Northern Han Chinese women, including 515 patients with preeclampsia and 703 healthy controls. No significant differences were detected in the allele frequencies between patients and controls (P = .23). When patients were divided into early-onset and late-onset preeclampsia according to gestational age of disease onset, the allele frequencies significantly differed between controls and patients with early-onset preeclampsia (P = .02). Genotype frequencies also were significantly different between controls and patients early-onset preeclampsia when data were analyzed under additive (P = .03) and dominant (P = .009) models. We replicated this association in an independent Northern Han Chinese population and observed a significant difference in the allele frequencies between patients with early-onset preeclampsia and controls (P = .011). We report that rs2681472 is associated with early-onset preeclampsia in Northern Han Chinese women.

Report this publication

Statistics

Seen <100 times