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Common genetic variants in the glucocorticoid receptor and the 11β-hydroxysteroid dehydrogenase type 1 genes influence long-term cognitive impairments in patients with Cushing's syndrome in remission.

Authors
  • Ragnarsson, Oskar1
  • Glad, Camilla A M
  • Berglund, Peter
  • Bergthorsdottir, Ragnhildur
  • Eder, Derek N
  • Johannsson, Gudmundur
  • 1 Institute of Medicine (O.R., C.A.M.G., R.B., G.J.), Institute of Neuroscience and Physiology (P.B.), and Vigilance and Neurocognition Laboratory (D.N.E.), Sahlgrenska Academy, University of Gothenburg, SE-413 45 Göteborg Sweden. , (Sweden)
Type
Published Article
Journal
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Publication Date
Sep 01, 2014
Volume
99
Issue
9
Identifiers
DOI: 10.1210/jc.2014-1906
PMID: 24915124
Source
Medline
License
Unknown

Abstract

In this study, polymorphisms in the 11βHSD1 and NR3C1 genes were associated with impaired cognitive function, indicating that GC sensitivity and prereceptor regulation of GC action may play a role in the long-term consequences of CS. The study provides a novel insight into the etiology of cognitive dysfunction in patients with CS in remission.

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