Common genetic variants in the glucocorticoid receptor and the 11β-hydroxysteroid dehydrogenase type 1 genes influence long-term cognitive impairments in patients with Cushing's syndrome in remission.
Institute of Medicine (O.R., C.A.M.G., R.B., G.J.), Institute of Neuroscience and Physiology (P.B.), and Vigilance and Neurocognition Laboratory (D.N.E.), Sahlgrenska Academy, University of Gothenburg, SE-413 45 Göteborg Sweden.
- Published Article
The Journal of Clinical Endocrinology & Metabolism
The Endocrine Society
- Publication Date
Sep 01, 2014
In this study, polymorphisms in the 11βHSD1 and NR3C1 genes were associated with impaired cognitive function, indicating that GC sensitivity and prereceptor regulation of GC action may play a role in the long-term consequences of CS. The study provides a novel insight into the etiology of cognitive dysfunction in patients with CS in remission.
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
This record was last updated on 01/13/2018 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/24915124