Affordable Access

Access to the full text

Common Functions of Disordered Proteins across Evolutionary Distant Organisms

Authors
  • Wallmann, Arndt
  • Kesten, Christopher1
  • 1 Department of Biology, ETH Zurich, 8092 Zurich, Switzerland
Type
Published Article
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Publication Date
Mar 19, 2020
Volume
21
Issue
6
Identifiers
DOI: 10.3390/ijms21062105
PMID: 32204351
PMCID: PMC7139818
Source
PubMed Central
Keywords
Disciplines
  • Review
License
Green

Abstract

Intrinsically disordered proteins and regions typically lack a well-defined structure and thus fall outside the scope of the classic sequence–structure–function relationship. Hence, classic sequence- or structure-based bioinformatic approaches are often not well suited to identify homology or predict the function of unknown intrinsically disordered proteins. Here, we give selected examples of intrinsic disorder in plant proteins and present how protein function is shared, altered or distinct in evolutionary distant organisms. Furthermore, we explore how examining the specific role of disorder across different phyla can provide a better understanding of the common features that protein disorder contributes to the respective biological mechanism.

Report this publication

Statistics

Seen <100 times