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A Common DIO2 Polymorphism And Alzheimer's Disease Dementia in African And European Americans.

Authors
  • McAninch, Elizabeth A1
  • Rajan, Kumar B2
  • Evans, Denis A2
  • Jo, Sungro1
  • Chaker, Layal3
  • Peeters, Robin P3
  • Bennett, David A4
  • Mash, Deborah C5
  • Bianco, Antonio C1
  • 1 Division of Endocrinology and Metabolism, Rush University Medical Center, Chicago, IL, USA.
  • 2 Department of Internal Medicine, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA.
  • 3 Rotterdam Thyroid Center, Erasmus University Medical Center, Rotterdam, The Netherlands. , (Netherlands)
  • 4 Department of Neurological Sciences, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
  • 5 Department of Neurological Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Type
Published Article
Journal
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Publication Date
Feb 22, 2018
Identifiers
DOI: 10.1210/jc.2017-01196
PMID: 29481662
Source
Medline
License
Unknown

Abstract

Thr92AlaD2 is associated with molecular markers known to underlie AD pathogenesis in AAs; this translates to an observed phenotype of increased odds of developing AD/dementia in AAs in these populations. Thr92AlaD2 may represent one factor contributing to racial discrepancies in incident AD.

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