A Common DIO2 Polymorphism And Alzheimer's Disease Dementia in African And European Americans.
Division of Endocrinology and Metabolism, Rush University Medical Center, Chicago, IL, USA.
Department of Internal Medicine, Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA.
Rotterdam Thyroid Center, Erasmus University Medical Center, Rotterdam, The Netherlands.
Department of Neurological Sciences, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Department of Neurological Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
- Published Article
The Journal of Clinical Endocrinology & Metabolism
The Endocrine Society
- Publication Date
Feb 22, 2018
Thr92AlaD2 is associated with molecular markers known to underlie AD pathogenesis in AAs; this translates to an observed phenotype of increased odds of developing AD/dementia in AAs in these populations. Thr92AlaD2 may represent one factor contributing to racial discrepancies in incident AD.
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This record was last updated on 06/09/2018 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/29481662