SUMMARY Currently, many people have been infected by the Coronavirus disease (COVID-19) and presented cardiorespiratory symptoms caused mainly by the host immune system response and respiratory tract inflammation. So far, there is no effective treatment to fight off COVID-19 and, despite many daily speculations about new treatments and vaccines, in this article, we discuss the effectiveness of a cheap and scientific proven technique to treat and prevent several diseases. Many studies have shown the benefits of physical exercise in individuals who have practiced it routinely. This approach is a great strategy to improve people's cardiorespiratory capacity, inflammation system, and immune response. Due to the quarantine period, the practice of physical exercise at home can also be used to fight off COVID-19 and must be inserted into people's routines.