Combining Radiotherapy with Immunocheckpoint Inhibitors or CAR-T in Renal Cell Carcinoma.
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Authors
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Santoni, Matteo1
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Heng, Daniel Y C2
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Aurilio, Gaetano3
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Iozzelli, Andrea4
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Servi, Lucilla5
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Fabiani, Andrea5
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Giannini, Massimo6
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Mazzucchelli, Roberta7
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Cimadamore, Alessia7
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Scarpelli, Marina7
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Zaghloul, Mohamed S8
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Battelli, Nicola1
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Montironi, Rodolfo7
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1
Oncology Unit, Macerata Hospital, via Santa Lucia 2, Macerata, Italy.
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(Italy)
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2
Department of Oncology, Tom Baker Cancer Center, University of Calgary, Calgary, AB, Canada.
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(Canada)
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3
IEO, European Institute of Oncology IRCCS, Medical Division of Urogenital and Head & Neck Cancer, Milan, Italy.
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(Italy)
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4
Radiology Unit, Macerata Hospital, via Santa Lucia 2, Macerata, Italy.
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(Italy)
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5
Urology Unit, Macerata Hospital, Via Santa Lucia 2, Macerata, Italy.
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(Italy)
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6
UOC Radioterapia Oncologica, Macerata Hospital, via Santa Lucia 2, Macerata, Italy.
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(Italy)
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7
Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy.
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(Italy)
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8
Radiotherapy Department, National Cancer Institute, Cairo University & Children's Cancer Hospital Egypt (CCHE), Cairo, Egypt.
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(Egypt)
- Type
- Published Article
- Journal
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Current drug targets
- Publication Date
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Jan 01, 2020
- Volume
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21
- Issue
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4
- Pages
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416–423
- Identifiers
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DOI: 10.2174/1389450120666191017113051
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PMID: 31625471
- Source
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Medline
- Keywords
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- Language
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English
- License
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Unknown
Abstract
Radiotherapy is considered a second life in Renal Cell Carcinoma (RCC) patients, mainly due to the introduction of immune checkpoint inhibitors, such as anti-Programmed-death (PD)-1, alone or in combination with anti-Cytotoxic T-Lymphocyte Antigen (CTLA)-4. Several trials are investigating the efficacy/safety of immune checkpoint inhibitors in sequential or combined strategies with radiotherapy. Chimeric Antigen Receptor (CAR)-T cells therapy as a promising approach in cancer patients has opened the way to novel possibilities of integrating therapies. The identification of biomarkers of tumor response to these combinations represents a challenge in RCC, together with the research for the best partner for immunotherapy in metastatic patients. In this review we illustrated preclinical/clinical data on the integration of radiotherapy with immunocheckpoint inhibitors or CART cells in RCC. Copyright© Bentham Science Publishers; For any queries, please email at [email protected]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
This record was last updated on 03/09/2020 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at
https://www.ncbi.nlm.nih.gov/pubmed/31625471
