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Combining EGFR inhibitors with radiation or chemotherapy: will preclinical studies predict clinical results?

Authors
  • Harari, Paul M
  • Huang, Shyh-Min
Type
Published Article
Journal
International Journal of Radiation Oncology*Biology*Physics
Publisher
Elsevier
Publication Date
Mar 01, 2004
Volume
58
Issue
3
Pages
976–983
Identifiers
PMID: 14967459
Source
Medline
License
Unknown

Abstract

By acknowledging the limitations of the available preclinical data and by expanding our mechanistic understanding of EGFR inhibitor function in representative tumor model systems, we should enhance our capacity to predict the most rational and successful methods to combine EGFR inhibitors with cytotoxic modalities in future clinical trials.

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