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Combined treatment with MK-801 and nicardipine reduces global ischemic damage in the gerbil.

Authors
Type
Published Article
Journal
Stroke; a journal of cerebral circulation
Publication Date
Volume
23
Issue
1
Pages
82–86
Identifiers
PMID: 1731424
Source
Medline

Abstract

Our results demonstrate that MK-801 plus nicardipine significantly attenuates CA1 cell death after forebrain ischemia in the gerbil. Excitatory amino acid antagonists in combination with Ca2+ channel antagonists may be an effective therapy in patients exposed to global ischemic insult.

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