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Combined lipase deficiency (cld): a lethal mutation on chromosome 17 of the mouse.

Authors
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Volume
221
Issue
4606
Pages
167–169
Identifiers
PMID: 6857276
Source
Medline
License
Unknown

Abstract

Two triglyceride lipases, lipoprotein lipase and hepatic triglyceride lipase, participate in the metabolism of plasma lipoproteins. A single recessive mutation, cld, on mouse chromosome 17 causes an apparent deficiency of both lipoprotein lipase and hepatic triglyceride lipase activities. Mice homozygous for this defect develop lethal hyperchylomicronemia within 2 days postpartum as a consequence of nursing. Plasma triglyceride values in affected mice often reach 20,000 milligrams per deciliter (100 times higher than that in normal littermates), and total lipase activity in plasma or tissues is 5 to 20 percent of that in controls.

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