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Combined evaluation of expressions of p53 and p21 proteins as prognostic factors for patients with gastric carcinoma.

Authors
  • Okuyama, Toshiro
  • Maehara, Yoshihiko
  • Kabashima, Akira
  • Takahashi, Ikuo
  • Kakeji, Yoshihiro
  • Sugimachi, Keizo
Type
Published Article
Journal
Oncology
Publication Date
Jan 01, 2002
Volume
63
Issue
4
Pages
353–361
Identifiers
PMID: 12417790
Source
Medline
License
Unknown

Abstract

The incidence in cases where functions of either or both of p53 and p21 proteins were diminished exceeded 70% of all the cases. The survival time for the p53(-)/p21(+) group with proper functions of both proteins and the signal pathway was significantly longer. The combined evaluation of expressions of p53 and p21 proteins in gastric cancer tissues aids in predicting the clinical prognosis for surgically treated gastric cancer patients.

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