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Combined effect of acute denervation and ischemia on the microcirculation of skeletal muscle.

Authors
  • Chen, L E
  • Seaber, A V
  • Urbaniak, J R
Type
Published Article
Journal
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Publication Date
Jan 01, 1992
Volume
10
Issue
1
Pages
112–120
Identifiers
PMID: 1727931
Source
Medline
License
Unknown

Abstract

Using direct in vivo videomicroscopy and a fluorescein dye technique, reperfusion injury after 3 h of ischemia was studied in the acutely denervated cremaster muscle of the rat. Compared with normally innervated controls, ischemia-induced reperfusion injury was more severe in the denervated group and included a delay of blood flow recovery, vortex formation, edema, hemorrhage, and vessel spasm. Vessel size was reduced at the arteriole and small artery level, and there was a decrease of reactive hyperemia. The injury mechanism may be related to a loss of active vasomotion and vascular response to vasoactive substances after denervation. The results suggest that shortening the ischemia time of denervated tissues may reduce ischemia-induced reperfusion injury. Similarly, given the same ischemia time, improved tissue reperfusion may be expected if the nerve supply is maintained.

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