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Combinatorial enzymatic synthesis of heparan sulfate.

Authors
  • Linhardt, Robert J
  • Kim, Jin-Hwan
Type
Published Article
Journal
Chemistry & Biology
Publisher
Elsevier
Publication Date
Sep 01, 2007
Volume
14
Issue
9
Pages
972–973
Identifiers
PMID: 17884627
Source
Medline
License
Unknown

Abstract

Escherichia coli K5 heparosan was enzymatically modified by Chen and colleagues to construct a library of heparan sulfate polysaccharides for evaluation, leading to the discovery that a 2-O-sulfoiduronic acid residue is not essential for antithrombin-mediated anticoagulant activity in larger oligosaccharide and polysaccharide structures.

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