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Combination therapy of rituximab and mycophenolate mofetil in childhood lupus nephritis.

Authors
  • Hogan, Julien1
  • Godron, Astrid2
  • Baudouin, Véronique3
  • Kwon, Theresa3
  • Harambat, Jérôme2
  • Deschênes, Georges3
  • Niel, Olivier3
  • 1 Pediatric Nephrology Department, Robert Debré Hospital, Assistance publique-Hôpitaux de Paris (APHP), Paris, France. [email protected] , (France)
  • 2 Pediatric Nephrology Unit, Pellegrin-Enfants Hospital-Bordeaux University, Bordeaux, France. , (France)
  • 3 Pediatric Nephrology Department, Robert Debré Hospital, Assistance publique-Hôpitaux de Paris (APHP), Paris, France. , (France)
Type
Published Article
Journal
Pediatric Nephrology
Publisher
Springer-Verlag
Publication Date
Jan 01, 2018
Volume
33
Issue
1
Pages
111–116
Identifiers
DOI: 10.1007/s00467-017-3767-4
PMID: 28780657
Source
Medline
Keywords
License
Unknown

Abstract

In our pediatric patients with LN, therapy with RTX + MMF combined with a rapid decrease in steroid appears to have been an efficacious treatment for severe LN but was associated with high rate of VZV infection. The potential of RTX to allow complete steroid avoidance warrants further investigation in children.

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