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Combination of metolazone and furosemide in the treatment of edema in the first month of life.

Authors
Type
Published Article
Journal
Child nephrology and urology
Publication Date
Volume
10
Issue
3
Pages
161–163
Identifiers
PMID: 2285924
Source
Medline
License
Unknown

Abstract

A combination of metolazone (0.2 mg/kg/day) and furosemide (4 mg/kg/day) was used in the treatment of a 2-week-old neonate who developed severe edema after cardiac surgery. The edema, which was initially responsive to furosemide, became resistant to high doses of this diuretic even with the concomitant use of ethacrynic acid. The addition of metolazone to furosemide induced prompt diuresis and natriuresis. This combination of diuretics can be helpful in the treatment of refractory edema in young infants.

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