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[Colorectal carcinoma in Cronkhite-Canada syndrome].

Authors
  • Zügel, N P
  • Hehl, J A
  • Jechart, G
  • Tannapfel, A
  • Wienbeck, M
  • Witte, J
Type
Published Article
Journal
Zeitschrift für Gastroenterologie
Publication Date
May 01, 2001
Volume
39
Issue
5
Pages
365–367
Identifiers
PMID: 11413916
Source
Medline
License
Unknown

Abstract

We report a 63-year-old lady with Cronkhite-Canada syndrome, who developed colorectal cancer. A hemicolectomy was performed, and the tumor specimen was prepared for DNA-analysis and immunohistochemical screening. We found a mutation of p53 gene without APC- and ras-gene alteration and expression of erbB2-protooncogen. The polyps in non-hereditary Cronkhite-Canada-syndrom are neither adenomatous nor hyperplastic, but patients often develop colorectal cancers. The steps of mutation do not follow the adenoma-carcinoma sequence, first described by Vogelstein 1988. This and previous observations suggest that carcinogenesis in Cronkhite-Canada syndrome follows another independent sequence.

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