We report a case of metastatic colorectal carcinoma detected by F-choline PET/CT. A 72-year-old man with history of prostate cancer (previously treated with prostatectomy) underwent F-choline PET/CT for restaging. PET/CT revealed a focal area of increased F-choline uptake corresponding to a rectal nodule. Furthermore, 2 areas of increased radiopharmaceutical uptake were evident in the right clavicle and in the body of the 10th dorsal vertebra, corresponding to the osteolytic lesions. Based on these PET/CT findings, the patient underwent biopsy of the rectal nodule and left clavicular lesion. Histologic examination demonstrated the presence of a colorectal carcinoma metastatic to the bone.