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[Colorectal cancer heterogeneity: the clinical impact of sporadic lesions arising via the serrated pathway].

Authors
  • Ágoston, Emese Irma1
  • Horváth, Evelin2
  • Győrffy, Balázs3
  • Harsányi, László1
  • Szász, A Marcell4
  • 1 I. Sebészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest.
  • 2 Hospital Universitario Son Espases Palma de Mallorca, Spanyolország.
  • 3 MTA-TTK Lendület Onkológiai Biomarker Munkacsoport Budapest.
  • 4 Onkológiai Központ, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest.
Type
Published Article
Journal
Orvosi hetilap
Publication Date
Feb 01, 2018
Volume
159
Issue
6
Pages
206–214
Identifiers
DOI: 10.1556/650.2018.30974
PMID: 29400100
Source
Medline
Keywords
License
Unknown

Abstract

Today, colorectal cancer is regarded as a heterogeneous disease. Its heterogeneity is caused by genetic alterations, molecular aberrations, different developing pathways as well as by micro- and macroenviromental agents. In the last decade, beside the classic genetic model for colorectal tumuorgenesis that follows the adenoma-carcinoma sequence, an alternative pathway has been identified. This pathway is called the serrated pathway and it is responsible for approximately one third of all colorectal lesions. Beyond their dissimilar molecular characteristics, these tumours also show different macroscopic and histologic appearance. Moreover, their malignant potency and progressive ability distinguish them from tumours of the classic genetic model. The aim of this review is to summarize the molecular and pathologic features of serrated lesions and the serrated pathway to colorectal cancer and to highlight their clinical impact. Orv Hetil. 2018; 159(6): 206-2014.

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