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Colonoscopy and µPET/CT are valid techniques to monitor inflammation in the adoptive transfer colitis model in mice.

Authors
Type
Published Article
Journal
Inflammatory Bowel Diseases
1536-4844
Publisher
Oxford University Press
Publication Date
Volume
19
Issue
5
Pages
967–976
Identifiers
DOI: 10.1097/MIB.0b013e3182802c7c
PMID: 23407045
Source
Medline
License
Unknown

Abstract

Adoptive transfer of CD4(+)CD25(-)CD62L(+) T cells in severe combined immunodeficient mice results in a moderate chronic colitis. Evolution of colitis could be monitored over time by both colonoscopy and µPET/CT. µPET/CT seems to detect inflammation at an earlier time point than colonoscopy. Both techniques represent reliable and safe methods without the need to kill animals.

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