Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Colonoscopy and µPET/CT are valid techniques to monitor inflammation in the adoptive transfer colitis model in mice.

Authors
  • Heylen, Marthe
  • Deleye, Steven
  • De Man, Joris G
  • Ruyssers, Nathalie E
  • Vermeulen, Wim
  • Stroobants, Sigrid
  • Pelckmans, Paul A
  • Moreels, Tom G
  • Staelens, Steven
  • De Winter, Benedicte Y
Type
Published Article
Journal
Inflammatory Bowel Diseases
Publisher
Oxford University Press
Publication Date
Apr 01, 2013
Volume
19
Issue
5
Pages
967–976
Identifiers
DOI: 10.1097/MIB.0b013e3182802c7c
PMID: 23407045
Source
Medline
License
Unknown

Abstract

Adoptive transfer of CD4(+)CD25(-)CD62L(+) T cells in severe combined immunodeficient mice results in a moderate chronic colitis. Evolution of colitis could be monitored over time by both colonoscopy and µPET/CT. µPET/CT seems to detect inflammation at an earlier time point than colonoscopy. Both techniques represent reliable and safe methods without the need to kill animals.

Report this publication

Statistics

Seen <100 times