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Colonic epithelium rejuvenation through YAP / TAZ

Authors
  • Chen, Rui1
  • Guan, Kun‐Liang1
  • 1 University of California, San Diego, USA , (United States)
Type
Published Article
Journal
The EMBO Journal
Publisher
EMBO
Publication Date
Dec 27, 2017
Volume
37
Issue
2
Pages
164–166
Identifiers
DOI: 10.15252/embj.201798618
PMID: 29282206
PMCID: PMC5770785
Source
PubMed Central
Keywords
License
Unknown
External links

Abstract

Stem cells are critical for normal tissue homeostasis and injury‐induced regeneration, but how wounding affects tissue regeneration at the cellular and molecular levels is not yet fully understood. A new study by Yui et al ( 2018 ) demonstrates that the extracellular matrix ( ECM ) remodeling modulates intestinal stem cells in tissue repair and regeneration via activation of the Hippo pathway effectors YAP / TAZ .

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