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Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans.

Authors
Type
Published Article
Journal
Neurosurgery
Publication Date
Volume
69
Issue
3
Pages
668–676
Identifiers
DOI: 10.1227/NEU.0b013e3182181ba8
PMID: 21430586
Source
Medline
License
Unknown

Abstract

Gd-DTPA may be able to accurately demonstrate the anatomic and volumetric distribution of large molecules used for antitumor therapy with high resolution and in combination with fluid-attenuated inversion recovery (FLAIR) imaging, and provide additional information about leaks into cerebrospinal fluid spaces and resection cavities. Similar studies should be performed in additional patients to validate our findings and help refine the methodologies we used.

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