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Colocalisation of intraplaque C reactive protein, complement, oxidised low density lipoprotein, and macrophages in stable and unstable angina and acute myocardial infarction.

Authors
  • Meuwissen, M
  • van der Wal, A C
  • Niessen, H W M
  • Koch, K T
  • de Winter, R J
  • van der Loos, C M
  • Rittersma, S Z H
  • Chamuleau, S A J
  • Tijssen, J G P
  • Becker, A E
  • Piek, J J
Type
Published Article
Journal
Journal of clinical pathology
Publication Date
Feb 01, 2006
Volume
59
Issue
2
Pages
196–201
Identifiers
PMID: 16443738
Source
Medline
License
Unknown

Abstract

The presence of CRP, complement, and oxLDL in a high proportion of plaque tissue from patients with unstable coronary artery disease implies that these surrogate markers have important proinflammatory effects inside atherosclerotic plaques. This may increase vulnerability to plaque rupture and thrombosis, with subsequent clinical sequelae.

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