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Collagen metabolism markers as a reflection of bone and soft tissue turnover during the menstrual cycle and oral contraceptive use.

Authors
Type
Published Article
Journal
Contraception
0010-7824
Publisher
Elsevier
Publication Date
Volume
61
Issue
4
Pages
265–270
Identifiers
PMID: 10899482
Source
Medline
Keywords
  • Biology
  • Clinical Research
  • Contraception
  • Contraceptive Methods
  • Developed Countries
  • Europe
  • Family Planning
  • Menstrual Cycle
  • Menstruation
  • Northern Europe
  • Oral Contraceptives
  • Physiology
  • Reproduction
  • Research Methodology
  • Research Report
  • Scandinavia
  • Skeletal Effects--Women
  • Sweden
  • Women

Abstract

Two different groups of women, 23 healthy young adults and 13 women with chronic posterior pelvic pain, were studied before and during use of oral contraceptives (OC). Collagen metabolism markers-here, the amino-terminal propeptide of type I procollagen, the carboxy-terminal telopeptide of type I collagen, and the amino-terminal of procollagen type III-as well as hormones and other endocrine factors indicating the balance between androgen expression/anabolism and catabolism of the subjects (testosterone, sex-hormone binding globulin, and insulin-like growth factor I were measured. Type I procollagen, the carboxy-terminal telopeptide of type I collagen, and the amino-terminal of procollagen type III were all significantly decreased during OC use. These findings implicate OC use-induced changes in collagen type I and III turnover. A shift in the anabolic/catabolic balance was also recorded indicating a less anabolic situation during OC use.

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