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COLLAGEN-LIKE PROTEIN IN HUMAN PLASMA.

Authors
  • KEISER, H
  • LEROY, E C
  • UDENFRIEND, S
  • SJOERDSMA, A
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Dec 27, 1963
Volume
142
Issue
3600
Pages
1678–1679
Identifiers
PMID: 14075703
Source
Medline
Keywords
License
Unknown

Abstract

Human plasma contains hydroxyproline in a bound form that is nondialyzable, is precipitable with the usual protein precipitants, can be extracted with hot trichloroacetic acid, and is released on hydrolysis in 6N HCI. These properties resemble those of collagen and suggest that small amounts of this connective tissue protein (3 to 5 mg per 100 ml), or a very large peptide derived from it, normally circulate in the blood. The identification and analysis of hydroxyproline in hydrolyzates of plasma protein were based on isotope-dilution procedures.

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