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Coincidence detection at the level of phospholipase C activation mediated by the m4 muscarinic acetylcholine receptor.

Authors
Type
Published Article
Journal
Current Biology
0960-9822
Publisher
Elsevier
Publication Date
Volume
5
Issue
5
Pages
536–544
Identifiers
PMID: 7583103
Source
Medline

Abstract

These studies demonstrate that the potency of m4-receptor-mediated PLC signaling is highly dependent upon the presence or absence of other PLC-activating agonists. The ability of the m4 receptor to evoke a strong, but conditional, activation of PLC may allow this type of receptor to participate in a coincidence-detection system that amplifies simultaneous PLC-activating signals through a mechanism involving crosstalk between PTX-sensitive and PTX-insensitive G-protein pathways.

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