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Cohesin-Dependent and -Independent Mechanisms Mediate Chromosomal Contacts between Promoters and Enhancers

Authors
  • Thiecke, Michiel J.1
  • Wutz, Gordana2
  • Muhar, Matthias2
  • Tang, Wen2
  • Bevan, Stephen1, 3
  • Malysheva, Valeriya1, 4, 5
  • Stocsits, Roman2
  • Neumann, Tobias2
  • Zuber, Johannes2
  • Fraser, Peter1, 6
  • Schoenfelder, Stefan1, 3
  • Peters, Jan-Michael2
  • Spivakov, Mikhail1, 4, 5
  • 1 Nuclear Dynamics Programme, Babraham Institute, Cambridge CB22 3AT, UK
  • 2 Research Institute of Molecular Pathology, Vienna Biocenter, Vienna 1030, Austria
  • 3 Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK
  • 4 MRC London Institute of Medical Sciences, London W12 0NN, UK
  • 5 Institute of Clinical Sciences, Faculty of Medicine, Imperial College, London W12 0NN, UK
  • 6 Department of Biological Science, Florida State University, Tallahassee, FL 32301, USA
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Jul 21, 2020
Volume
32
Issue
3
Identifiers
DOI: 10.1016/j.celrep.2020.107929
PMID: 32698000
PMCID: PMC7383238
Source
PubMed Central
Keywords
License
Unknown

Abstract

Thiecke et al. use Capture Hi-C to detect the rewiring of promoter-anchored chromosomal contacts upon rapid degradation of the architectural proteins cohesin and CTCF . They find that a significant minority of promoter-enhancer contacts are maintained under these conditions, with implications for long-range transcriptional control.

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