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Cognitive Variability Predicts Incident Alzheimer's Disease and Mild Cognitive Impairment Comparable to a Cerebrospinal Fluid Biomarker.

Authors
  • Gleason, Carey E1, 2, 3
  • Norton, Derek3, 4
  • Anderson, Eric D5
  • Wahoske, Michelle1, 3
  • Washington, Danielle T1, 2, 3
  • Umucu, Emre6
  • Koscik, Rebecca L7
  • Dowling, N Maritza8
  • Johnson, Sterling C1, 2, 3, 8
  • Carlsson, Cynthia M1, 2, 3, 8
  • Asthana, Sanjay1, 2, 3, 8
  • 1 Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
  • 2 Geriatric Research, Education and Clinical Center (11G), William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
  • 3 Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA.
  • 4 University of Wisconsin, Department of Biostatistics and Medical Informatics, Madison, WI, USA.
  • 5 Wright State University, School of Education and Human Services, Dayton, OH, USA.
  • 6 Department of Rehabilitation Sciences, University of Texas at El Paso, El Paso, TX, USA.
  • 7 Wisconsin Alzheimer's Institute, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
  • 8 George Washington University, School of Nursing, Washington, DC, USA.
Type
Published Article
Journal
Journal of Alzheimer s Disease
Publisher
IOS Press
Publication Date
Jan 01, 2018
Volume
61
Issue
1
Pages
79–89
Identifiers
DOI: 10.3233/JAD-170498
PMID: 29125485
Source
Medline
Keywords
License
Unknown

Abstract

These analyses provide preliminary support for IICV as a marker of incident AD and MCI. This easily-disseminated, non-invasive marker compared favorably to well-established CSF biomarkers.

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