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Cognitive reserve: a multidimensional protective factor in Parkinson's disease related cognitive impairment.

Authors
  • Ciccarelli, Nicoletta1
  • Colombo, Barbara2
  • Pepe, Fulvio3
  • Magni, Eugenio3
  • Antonietti, Alessandro1
  • Silveri, Maria Caterina1
  • 1 Department of Psychology, Catholic University of Milan, Italy. , (Italy)
  • 2 Neuroscience Lab, Champlain College, Burlington, VT, USA.
  • 3 Department of Neuroscience, Poliambulanza Foundation, Brescia, Italy. , (Italy)
Type
Published Article
Journal
Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition
Publication Date
Jul 01, 2022
Volume
29
Issue
4
Pages
687–702
Identifiers
DOI: 10.1080/13825585.2021.1892026
PMID: 33629649
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

We explored the association between cognitive reserve (CR) and Parkinson' s disease (PD) related cognitive deterioration.Forty PD patients and 12 matched healthy controls (HC) were enrolled. The PD group was balanced for the presence/absence of cognitive impairment. All participants underwent MOCA. CR was measured by the Brief Intelligence Test, and a new comprehensive tool, named Cognitive Reserve Test (CoRe-T), including sections on leisure activities and creativity.Participants with higher CR obtained a better MOCA score irrespective of the group they belonged to. At the same time, irrespective of the CR level, the performance of the HC group was always better in comparison to the PD group. Within the PD group, a higher frequency of leisure activities was associated to be cognitively unimpaired, independently by the severity of motor symptoms and age.CR could help to cope with PD-related cognitive decline. Its multidimensional nature could have important applications in prevention and rehabilitation interventions.

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