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Cognitive impairment in nondemented Parkinson's disease.

Authors
  • Barone, Paolo
  • Aarsland, Dag
  • Burn, David
  • Emre, Murat
  • Kulisevsky, Jaime
  • Weintraub, Daniel
Type
Published Article
Journal
Movement Disorders
Publisher
Wiley (John Wiley & Sons)
Publication Date
Dec 01, 2011
Volume
26
Issue
14
Pages
2483–2495
Identifiers
DOI: 10.1002/mds.23919
PMID: 22170275
Source
Medline
License
Unknown

Abstract

A substantial percentage of patients with newly diagnosed Parkinson's disease without dementia are reported to be affected by cognitive impairment (CI). In practice, however, CI is underrecognized, as the signs may not be apparent in early-stage disease and many routine assessment tools lack the sensitivity to detect subtle cognitive dysfunction. Patients with PD and mild CI (MCI) may have a higher risk of developing dementia than cognitively intact PD patients; however, it is not currently known which patients with CI are at increased risk of developing dementia. This review summarizes current knowledge about CI in nondemented PD; it discusses the structural and functional changes associated with CI and addresses areas of unmet needs. We focus on questions that should be addressed in future studies to achieve consensus on its characteristics and definition, pathophysiology, epidemiology, diagnosis and assessment, and treatment and management.

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