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Cognitive Genomics: Recent Advances and Current Challenges

Authors
  • Fitzgerald, Joan1
  • Morris, Derek W.1
  • Donohoe, Gary1
  • 1 National University of Ireland Galway, Rm 1040 School of Psychology, University Road, Galway, Ireland , Galway (Ireland)
Type
Published Article
Journal
Current Psychiatry Reports
Publisher
Springer-Verlag
Publication Date
Jan 10, 2020
Volume
22
Issue
1
Identifiers
DOI: 10.1007/s11920-019-1125-x
Source
Springer Nature
Keywords
License
Yellow

Abstract

Purpose of ReviewWe review recent progress in uncovering the complex genetic architecture of cognition, arising primarily from genome-wide association studies (GWAS). We explore the genetic correlations between cognitive performance and neuropsychiatric disorders, the genetic and environmental factors associated with age-related cognitive decline, and speculate about the future role of genomics in the understanding of cognitive processes.Recent FindingsImprovements in genomic methods, and the increasing availability of large datasets via consortia cooperation, have led to a greater understanding of the role played by common and rare variants in the genomics of cognition, the highly polygenic basis of cognitive function and dysfunction, and the multiple biological processes involved.SummaryRecent research has aided in our understanding of the complex biological nature of genomics of cognition. Further development of data banks and techniques to analyze this data hold significant promise for understanding cognitive ability, and for treating cognitively related disability.

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