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Coffee consumption decreases the connectivity of the posterior Default Mode Network (DMN) at rest

  • Picó-Pérez, Maria1, 2, 3, 4
  • Magalhães, Ricardo1, 2
  • Esteves, Madalena1, 2
  • Vieira, Rita1, 2, 3
  • Castanho, Teresa C.1, 2, 3, 5
  • Amorim, Liliana1, 2, 3, 5
  • Sousa, Mafalda1, 2, 3
  • Coelho, Ana1, 2
  • Moreira, Pedro S.1, 2, 6
  • Cunha, Rodrigo A.7
  • Sousa, Nuno1, 2, 3, 5
  • 1 Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, Braga , (Portugal)
  • 2 ICVS/3B's - PT Government Associate Laboratory, Braga/Guimaraes , (Portugal)
  • 3 Clinical Academic Center – Braga, Braga , (Portugal)
  • 4 Departamento de Psicología Básica, Clínica y Psicobiología, Universitat Jaume I, Castellón de la Plana , (Spain)
  • 5 P5 Medical Center, Braga , (Portugal)
  • 6 Psychological Neuroscience Lab, CIPsi, School of Psychology, University of Minho, Braga , (Portugal)
  • 7 CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra , (Portugal)
Published Article
Frontiers in Behavioral Neuroscience
Frontiers Media SA
Publication Date
Jun 28, 2023
DOI: 10.3389/fnbeh.2023.1176382
  • Behavioral Neuroscience
  • Original Research


Habitual coffee consumers justify their life choices by arguing that they become more alert and increase motor and cognitive performance and efficiency; however, these subjective impressions still do not have a neurobiological correlation. Using functional connectivity approaches to study resting-state fMRI data in a group of habitual coffee drinkers, we herein show that coffee consumption decreased connectivity of the posterior default mode network (DMN) and between the somatosensory/motor networks and the prefrontal cortex, while the connectivity in nodes of the higher visual and the right executive control network (RECN) is increased after drinking coffee; data also show that caffeine intake only replicated the impact of coffee on the posterior DMN, thus disentangling the neurochemical effects of caffeine from the experience of having a coffee.

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