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The coexistence of substance P- and glutamic acid decarboxylase-like immunoreactivity in entopeduncular neurons of the rat.

Authors
  • Murakami, S
  • Kubota, Y
  • Kito, S
  • Shimada, S
  • Takagi, H
  • Wu, J Y
  • Inagaki, S
Type
Published Article
Journal
Brain Research
Publisher
Elsevier
Publication Date
Apr 24, 1989
Volume
485
Issue
2
Pages
403–406
Identifiers
PMID: 2470475
Source
Medline
License
Unknown

Abstract

The coexistence of substance P- and glutamic acid decarboxylase-like immunoreactivity in cell bodies was investigated in the entopeduncular neurons of the rat by the double-immunofluorescence method using species-specific antibodies. Over half of the substance P-like immunoreactive cells were GABAergic. Double-labeled neurons were generally seen in the rostral to the middle region of the entopeduncular nucleus. Since the rostral portion of the entopeduncular nucleus mainly projects to the lateral habenular nucleus, it is suggested that double-labeled neurons in the entopeduncular nucleus largely project to the lateral habenular nucleus which is involved in the limbic system.

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