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Coevolving Plasmids Drive Gene Flow and Genome Plasticity in Host-Associated Intracellular Bacteria

Authors
  • Köstlbacher, Stephan1
  • Collingro, Astrid1
  • Halter, Tamara1
  • Domman, Daryl2, 3
  • Horn, Matthias1
  • 1 University of Vienna, Centre for Microbiology and Environmental Systems Science, Division of Microbial Ecology, Althanstrasse 14, Vienna 1090, Austria
  • 2 Wellcome Sanger Institute, Parasites and Microbes Programme, Hinxton, Cambridge CB10 1SA, UK
  • 3 Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Type
Published Article
Journal
Current Biology
Publisher
Cell Press
Publication Date
Jan 25, 2021
Volume
31
Issue
2
Pages
346–357
Identifiers
DOI: 10.1016/j.cub.2020.10.030
PMID: 33157023
PMCID: PMC7846284
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

Köstlbacher et al. illustrate how plasmids of intracellular bacteria in the phylum Chlamydiae have coevolved with their hosts over a billion years. By mobilizing chromosomal genes, plasmids contributed to host adaptation and might have mitigated the degenerative effects of Muller’s ratchet in this group of intracellular pathogens and symbionts.

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