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Codon Usage and Splicing Jointly Influence mRNA Localization

Authors
  • Mordstein, Christine1, 2
  • Savisaar, Rosina2, 3
  • Young, Robert S.1, 4
  • Bazile, Jeanne1
  • Talmane, Lana1
  • Luft, Juliet1
  • Liss, Michael5
  • Taylor, Martin S.1
  • Hurst, Laurence D.2
  • Kudla, Grzegorz1
  • 1 MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK
  • 2 Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, UK
  • 3 Instituto de Medicina Molecular, João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
  • 4 Centre for Global Health Research, Usher Institute, The University of Edinburgh, Edinburgh, UK
  • 5 Thermo Fisher Scientific, GENEART GmbH, Regensburg, Germany
Type
Published Article
Journal
Cell Systems
Publisher
Cell Press
Publication Date
Apr 22, 2020
Volume
10
Issue
4
Pages
351–362
Identifiers
DOI: 10.1016/j.cels.2020.03.001
PMID: 32275854
PMCID: PMC7181179
Source
PubMed Central
Keywords
License
Unknown

Abstract

Mordstein et al. report an unexpected effect of splicing in human cells, whereby splicing preferentially enhances the expression of genes with low GC content. This might partially explain the high number of introns found in mammalian genomes.

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