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Cochlear potentials and their modulation by low-frequency sound in early endolymphatic hydrops.

Authors
  • Klis, J F1
  • Smoorenburg, G F
  • 1 Department of Otorhinolaryngology, University Hospital Utrecht, The Netherlands. , (Netherlands)
Type
Published Article
Journal
Hearing Research
Publisher
Elsevier BV
Publication Date
Jan 01, 1988
Volume
32
Issue
2-3
Pages
175–184
Identifiers
PMID: 3360677
Source
Medline
License
Unknown

Abstract

Seventeen guinea pigs were unilaterally operated to produce endolymphatic hydrops. After 2 wk (9 animals) or 4 wk (8 animals), extracochlear electrophysiological responses to tone bursts of several frequencies were recorded in both the operated and non-operated ears. In addition, modulation by low-frequency (29 Hz sinusoidal bias) sound of the responses to 8 kHz tonebursts was measured. After the electrophysiological measurements, the animals were killed and examined histologically. Four weeks after the operation, cochlear microphonics in response to a 500 Hz tone burst and to the 29 Hz bias were significantly smaller in the operated ears. The summating potential showed a tendency to be larger in the operated ears. The compound action potential input-output curves for 2 kHz probes showed a small threshold shift accompanied by steep slopes, reminiscent of recruitment. Modulation of summating potentials by the low-frequency bias was smaller on the operated side. In most cochleae an endolymphatic hydrops was observed. Three cochleae showed a collapse of Reissner's membrane.

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